Dexanabinol Phase-3 Trial Disappointing
Back in August I posted about a new drug that was being developed here in New Jersey that was thought to be a promising new treatment for traumatic brain injuries. The drug, dexanabinol was developed by Pharmos and had thought to be able to assist in minimizing the damage caused by a traumatic brain injury by preventing swelling of the brain. Unfortunately today it was announced that in the Phase-3 trial of dexanabinol, the drug failed to show statistically significant improvement in a patient’s ability to regain more of their memory and other high-level function following a severe blow to the head. You can read more about this story here.
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Well, just hypothermia and hyperbaric are both recognized for brain insults.
Magnesium is important to block the NMDA
receptor and most people have a deficiency.
Of course, I am wondering about the value
of a cannabinoid that isn’t a CB1 and CB2
agonist. I would certainly call Dr. Lester
Grinspoon at Harvard. There is such a battle to get a patentable drug to market and they ignore well tested things like THC. With that type of injury it is important not to worry about whether it is psychoactive or not…you aren’t leaving the hospital. Believe me the
psychoactive “side effects” of neuroleptics and tricyclics are worse until you learn to live with them and that is why people spend time in the psychiatric ward coming to terms with these drugs.
Well, just hypothermia and hyperbaric are both recognized for brain insults.
Magnesium is important to block the NMDA
receptor and most people have a deficiency.
Of course, I am wondering about the value
of a cannabinoid that isn’t a CB1 and CB2
agonist. I would certainly call Dr. Lester
Grinspoon at Harvard. There is such a battle to get a patentable drug to market and they ignore well tested things like THC. With that type of injury it is important not to worry about whether it is psychoactive or not…you aren’t leaving the hospital. Believe me the
psychoactive “side effects” of neuroleptics and tricyclics are worse until you learn to live with them and that is why people spend time in the psychiatric ward coming to terms with these drugs.